Small Animal Internal Medicine is the branch of medicine specializing in diseases of the gastrointestinal tract, endocrine system, hematology, respiratory tract, kidneys and urinary tract, and infectious diseases. Common disorders seen by Internists include hormonal imbalances such as Cushing’s or Addison’s, hyperthyroidism, hypothyroidism, diabetes, liver disease, and chronic kidney disease. Abdominal ultrasound, CT scans, specialized blood tests, and scoping procedures are common diagnostic tools. Our Small Animal Internal Medicine service has many studies involving these disorders as well as new treatment options, so please check back often to see if your pet may qualify to enroll in one of our studies. Thank you!
*NEW STUDY* - Cats with FIP and their unaffected housemates
We are recruiting cats who have been diagnosed with FIP. The study is to investigate the hypothesis that FIP is caused by both a mutation of enteric coronavirus and a change in the cat's antibody response. Investigators will be comparing the virus that normally lives in the GI tract and the mutated version in the blood and abdominal fluid. They can then further look at the individual cat's antibody response to both versions.
Boxers with lymphoma
The Small Animal Internal Medicine and Oncology services are currently recruiting Boxers with lymphoma. They are looking to determine whether exposure to certain environmental chemicals contributes to lymphoma risk in Boxer dogs. Investigators hope the results of this study will help find better ways to prevent lymphoma in dogs.
Eligibility: Any purebred Boxer dog diagnosed with lymphoma by a veterinarian performing cytology or biopsy, and any healthy unaffected Boxers of the same age and sex to act as controls.
Owners will collect a voided 25 mL urine sample (about 2 tablespoons) at home using a kit that is provided. Owners will also be asked to fill out a questionnaire about the dog's household and collect drinking water and air samples from the home using materials provided by the study.
The samples and environmental questionnaire will be processed by Dr. Lauren Trepanier's laboratory. Please contact Hannah Peterson or Dr. Lauren Trepanier with any questions or to obtain a sampling kit and questionnaire.
Clinically Healthy Dogs
The Small Animal Internal Medicine Service is helping the NC State College of Veterinary Medicine to screen dogs for bladder and prostate cancer, called urothelial carcinoma or transitional cell carcinoma (UC/TCC).
They are looking to determine if the CADET® BRAF Mutation Detection Assay can be used to diagnose UC/TCC before clinical signs develop. Investigators hope that early diagnosis will allow them to initiate treatment earlier to delay progression and improve survival for dogs with this disease.
Eligibility: Any clinically healthy American Eskimo Dog, Beagle, Jack Russell Terrier, Scottish Terrier, Shetland Sheepdog, or West Highland White Terrier that is at least 6 years of age with no sign of urinary tract infection.
If interested in applying to participate in this study, you can do so here. You can view a short video about this study on the NC State College of Veterinary Medicine Facebook page. Please contact Amy Elbe, CVT, LAT or Dr. Michael Wood with any questions.
Dogs with BLADDER CANCER
The Small Animal Internal Medicine and Oncology Services are recruiting patients with bladder tumors. They interested in determining whether urinary exposure to certain environmental chemicals contributes to bladder cancer risk in the dog. A second part of this study is to determine whether owners of dogs with bladder cancer have similar urinary chemical exposures.
They are looking to obtain a urine sample from dogs of any breed diagnosed with bladder cancer. Owners will be asked to complete a questionnaire about their dog's environment. It is optional for owners to also provide their own urine sample and to collect household dust, drinking water, and air samples from their home.
Eligibility: Any dog diagnosed with transitional cell carcinoma of the bladder or urethra, or any dog that is identified as an unaffected matched control. Dogs should ideally be enrolled prior to any surgery or chemotherapy.
Owners will collect a 25 mL urine sample (about 2 tablespoons) from their dog at home with a special kit. Materials will also be provided for additional optional sample collection at home. Please contact Hannah Peterson or Dr. Lauren Trepanier with any questions or to obtain a sampling kit and questionnaire.