For additional information please call the Oncology Service at (608) 890-0422 or email at firstname.lastname@example.org
Evaluation of a Targeted Radiation Treatment Combined with an Immunotherapy Treatment for Dogs with Metastatic Cancer with an accessible tumor
(Except Mast Cell Tumor & Hemangiosarcoma)
In collaboration with the UW Carbone Cancer Center and the National Cancer Institute, we are developing a new approach to the treatment of cancers that have spread beyond the original cancer site. These investigational treatments are designed to stimulate the patient’s immune system to recognize and destroy the cancer wherever it may be in the body. This new immunotherapy combines standard radiation therapy with a low-dose whole-body injectable radiation therapy that targets the metastatic cancer sites and an immune stimulant injected directly into the original tumor. Laboratory evidence suggests this strategy improves the anti-cancer potency of the immunotherapy.
Dogs will first receive advanced imaging (standard PET/CT imaging). The findings of these scans will determine the dose which will be delivered intravenously one week later along with standard radiation therapy to the primary cancer.
One week after radiation therapy, the dog will receive an immunotherapy agent administered directly into the dog’s tumor, once daily for 3 days. Because the imaging agent and the intravenous radiation agent are radioactive, dogs must remain in the hospital until the level of radioactivity has dropped to a safe level to allow the dog to return home; this will be approximately 4 – 6 days following administration of the imaging agent or the intravenous radiation treatment.
All costs associated with initial screening to determine eligibility and costs associated with treatment, scans, hospitalizations, and study follow-up are paid for by the study. In addition, a $3000 credit will be applied to your UW Veterinary Care account as a rescue therapy reimbursement that can be used towards alternative therapy here at UW Veterinary Care should the cancer progress after immunotherapy.
*NEW* – Dogs with Histologically confirmed, high-grade lymphoma or non-sarcomatous solid tumors
This is a trial led by the National Cancer Institute (NCI) to assesses the safety and effectiveness of TdCyd and Aza-TdC, novel anticancer agents in dogs with cancer. This study will complement currently open human trials designed to test new doses and effects of these agents.
Both newly diagnosed and those with recurrent/relapsed disease are eligible to participate.
Prior to entry into this study, your dog must have a confirmed diagnosis of cancer and staging tests to ensure his/her general health and to evaluate how advanced the disease is prior to treatment. Costs to owner before confirming eligibility: $750-1000, depending on type of cancer and tests already done. These are routine staging costs and will be used to determine eligibility for the study.
Within this study, we will obtain serial biopsies of your dog’s tumor. A biopsy will be collected prior to the first dose of drug (pre-treatment), on Day 8, Day 12 and possibly on Day 22 depending on how your dog has responded to therapy. Each of these biopsy sessions will occur under sedation or general anesthesia. Your dog will return to the UW on Days 8, 12, 15 and 22. Serial blood collections (5 time points) will occur on Day 1 of the study. Subsequent, single collections will occur on Days 8, 12, 15 and 22. You will be required to administer study medication at home on Days 2, 3, 4, 5, 9, 10, and 11. If any complications arise from study drug administration, their management will be covered by study funds.
Dogs with Bladder Cancer
*NEW 4/5/22* – Dogs with LymphomA
We are evaluating the effectiveness and safety of verdinexor for the treatment of Lymphoma in dogs. The study will evaluate verdinexor compared to a placebo (a tablet that does not contain verdinexor). Dogs will have a 1 in 5 chance of receiving the placebo. Your participation in the study will be for 56 days, during which time you will need to bring your dog to UW Veterinary Care for scheduled or unscheduled follow-up visits.
- Owner Requirements: Your dog’s living environment and feeding habits during the duration of the study are up to you – at your discretion, except that you must give the investigational treatment with food or just after feeding your dog a meal or a “snack”.
- Study Visits: You will need to bring your dog in to UW Veterinary Care for the Day 0, 7 (± 2), 14 (± 2), 28 (± 3), 42 (± 3) and 56 (± 3) visits. Depending on how your dog is feeling, you may also be required to bring him/her for unscheduled visits. You will receive a phone call on Day 4 to determine if your dog should be re-evaluated before the scheduled Day 7 visit.
- Dosing: You will dose your dog at home orally twice per week with at least 72 hours between doses, at approximately the same time each day and record this information
- Monitoring: You should monitor your dog for any abnormal health observation during the study and record this information. You must contact the veterinarian as soon as possible should you have any concern.
- Costs: If you elect to enroll your dog in the study, the study will provide the investigational treatment to be used during the study and pay for the study-related cost of the examinations and tests. If your dog has any adverse events that are study related and require treatment, the study will cover the costs of reasonable treatment.
Lymphoma in Boxer Dogs:
Environmental Chemicals and Lymphoma in Boxer Dogs
Lymphoma is a fatal cancer of the blood cells in dogs. The boxer breed is at higher risk, but the reasons for this are not understood. Lymphoma in people is associated with toxic chemicals in the environment. We are looking to see if the same is true for dogs. The goal of this study is to see whether certain environmental chemicals contribute to lymphoma risk in dogs, starting with the boxer breed.
Any purebred boxer dog diagnosed with lymphoma by a veterinarian performing cytology or biopsy may be eligible for this study. Dogs must be enrolled before any chemotherapy is started, but prednisone is allowed. We are also seeking healthy unaffected boxers to act as controls. The owner will collect a voided 25 mL urine sample (about 2 tablespoons) from the dog using a kit that will be mailed to the dog’s home. We also ask the owner to fill out a questionnaire about their dog’s household environment and to collect drinking water and air samples from the home using materials that we provide.
Dogs with Any Malignant Tumor (except lymphoma or leukemia)
The purpose of this study is to evaluate a novel approach to stimulate a dog’s own immune cells to fight against the dog’s tumor. Recent evidence in rodent models suggest that a very brief incubation of a sample of immune cells present in the blood (T-cells) with a novel immune-stimulating agent results in significant activation of the T-cells and these activated T-cells can have substantial antitumor activity. To investigate this treatment, evaluation of administration of a dog’s own activated T-cells will be performed in dogs with spontaneous malignant tumors.
The treatment procedure involves collecting a blood sample from the dog, isolating T-cells, and exposing the T-cells to the novel activator. The activated T-cells are then administered intravenously to the same dog on the same day. Treatment will be administered every other week for 8 treatments. To date we have observed no adverse effects. Dogs will be monitored closely for tumor response and potential side-effects.
Lymphoma in Dogs:
Evaluation of Laverdia (new drug) in combination with CCNU
This study is to evaluate the use of a novel drug (Laverdia) in combination with CCNU (lomustine) in dogs with multicentric large cell lymphoma that have failed previous chemotherapy treatments. Dogs must weigh over 10 kg.
Owners will need to pay for costs associated with diagnosis and confirming eligibility.
The study will pay for all treatments and costs of recheck appointments and blood work at weeks 0, 1, 3, 4, 6, 7, 9, 10, 12, 13, 15.
Melanoma Without Metastasis:
Evaluation of a Novel Immunotherapy in Combination with Radiation Therapy in Dogs
ATTENTION! We have recently completed enrollment into phase 1 and phase 2 of this trial. Phase 3 of this trial has not started yet. Please follow this page for updates as to when enrollment will begin.
In a study funded by the Veterans Administration we will evaluate the effect of a novel immunotherapy agent administered into the tumor in combination with radiation therapy.
Dogs with melanoma that have a tumor accessible for intratumor injection may be eligible for this study. There will be 2 treatment groups: one group will receive one dose of radiation and one group will receive 3 doses of radiation, both groups will then receive daily injections for 3 days of the immunotherapy agent into the the tumor. Following treatment, dogs will return to UWVC for evaluation on days 10, 17, 24, 30, and 60.
Once a dog is deemed eligible for the study, all costs related to the study will be covered including the radiation therapy and immunotherapy.
Dogs With Osteosarcoma:
Inhaled IL-15 Combined with Amputation and Chemotherapy
The purpose of this study is to evaluate the addition of immunotherapy with inhaled IL-15 (an immunostimulatory molecule called a cytokine) to the standard treatment in patients with osteosarcoma to see if it improves outcome. Our group, as well as others, have found that immunotherapy with inhaled cytokines can cause large osteosarcoma tumors in the lungs of dogs to shrink. Because the lungs are most often the first site for these tumors to spread, we believe that treating earlier when fewer cells are in the lungs could improve the outcomes seem with chemotherapy alone.
Dogs with osteosarcoma of the leg may be eligible for this study. Then beginning within 4 days after amputation, the dog will receive inhaled IL-15 twice daily for 2 weeks. The first dose will be given prior to discharge and the owner will be responsible for the remainder of inhaled treatments at home. Owners will be instructed on how to perform the inhalation and all supplies needed for this will be provided. Once inhalation treatments are completed, dogs will receive standard of care chemotherapy (carboplatin). The costs associated with IL-15 treatment will be covered by the study. The owner is responsible for the cost of amputation and chemotherapy.