Clinically Healthy Dogs
The Small Animal Internal Medicine Service is helping the NC State College of Veterinary Medicine to screen dogs for bladder and prostate cancer, called urothelial carcinoma or transitional cell carcinoma (UC/TCC).
They are looking to determine if the CADET® BRAF Mutation Detection Assay can be used to diagnose UC/TCC before clinical signs develop. Investigators hope that early diagnosis will allow them to initiate treatment earlier to delay progression and improve survival for dogs with this disease.
Eligibility: Any clinically healthy American Eskimo Dog, Beagle, Jack Russell Terrier, Scottish Terrier, Shetland Sheepdog, or West Highland White Terrier that is at least 6 years of age with no sign of urinary tract infection.
If interested in applying to participate in this study, you can do so here. You can view a short video about this study on the NC State College of Veterinary Medicine Facebook page. Please contact Amanda Brooks at firstname.lastname@example.org or Dr. Michael Wood at email@example.com with any questions.
clinically healthy greyhounds
The Small Animal Internal Medicine Service is recruiting clinically healthy adult Greyhound dogs with no recent or chronic illness. They are investigating why Greyhound dogs have higher levels of the metabolite homocysteine compared to other dog breeds.
They are looking to obtain blood and urine samples from healthy Greyhound and non-Greyhound dogs.
Eligibility: Any clinically healthy adult Greyhound or non-Greyhound dog with no recent or chronic illness may be a candidate for this study.
This study will help promote better understanding of a unique blood abnormality found within the Greyhound breed, which may help treat Greyhounds in the future. Results of this study may support followup studies on genetic mechanisms for this abnormality.
Dogs with BLADDER CANCER
The Small Animal Internal Medicine and Oncology Services are recruiting patients with bladder tumors. They are interested in whether exposure to certain environmental chemicals contributes to the risk of bladder cancer in dogs.
They are looking to obtain a urine sample from dogs of any breed diagnosed with bladder cancer. In addition, we have an environmental exposure questionnaire for dog owners to fill out.
Eligibility: Any dog diagnosed with transitional cell carcinoma of the bladder or urethra. Dogs should ideally be enrolled prior to any surgery or chemotherapy. We will collect a 25 mL urine sample (about 2 tablespoons), either at UW Veterinary Care or at home with a special kit.
The urine and environmental questionnaire will be processed by Dr. Lauren Trepanier's laboratory. Please contact Torrey Tiedeman at firstname.lastname@example.org or Dr. Lauren Trepanier at email@example.com with any questions or to obtain a urine sampling kit.
Dogs with chronic gastrointestinal signs
The Small Animal Internal Medicine Service is recruiting patients with chronic vomiting, diarrhea, poor appetite, and weight loss. They are investigating whether or not dogs need to be fasted for a commonly recommended test in dogs with these symptoms.
They are looking to obtain blood samples at scheduled times throughout the course of a day from dogs affected by chronic vomiting, diarrhea, poor appetite, and weight loss.
Eligibility: Any adult medium-to-large breed dog experiencing the above-noted symptoms. All dogs must be willing to eat a normal meal in the hospital setting. All dogs must be current patients of UW Veterinary Care and be first evaluated by a veterinarian.
This study may indicate that the current standard fasting requirements for the gastrointestinal panel blood test are not necessary. Removing or reducing these fasting requirements will result in decreased patient stress, as well as reduction of challenges for owners and clinicians in the investigation of chronic gastrointestinal disease.