Orthopaedic patient studies at the UW Veterinary Care are done in collaboration with the Comparative Orthopaedic Research Laboratory (CORL). This is a multidisciplinary research group focused on solving orthopaedic problems that affect animals and humans. CORL is located in the School of Veterinary Medicine, University of Wisconsin-Madison. One of the laboratory’s greatest attributes is the strong collaborative relationships that exist between the laboratory, the School of Medicine and the College of Engineering. Financial support for the laboratory includes both federal and non-federal funding agencies, medical and veterinary foundations, corporate partners, and private donors. For more information, please visit http://www.vetmed.wisc.edu/lab/corl/.
Nutraceutical Treatment for Osteoarthritis in Dogs
Enrollment for this study is currently filled.
The Small Animal Orthopaedic Service is looking for medium to large breed dogs with hip, knee, or ankle arthritis to participate in a placebo-controlled clinical trial evaluating a new type of nutraceutical food supplement for management of dogs with poor mobility because of arthritis.
It is anticipated that the nutraceutical treatment will improve patient mobility. Pain-relieving rescue medication will be available for all dogs during the trial. Dogs typically receive a free clinical examination and radiographic assessment. Owners will receive a financial benefit at trial completion. Participation will contribute to determining whether a new type of nutraceutical treatment for arthritis is effective.
For more information and brochures, please visit http://www.vetmed.wisc.edu/lab/corl/canine-studies/
If this trial demonstrates that the nutraceutical food supplement is effective, we anticipate that this treatment will be offered routinely through UW Veterinary Care. This trial is supported by a gift to the University of Wisconsin Foundation.
Dogs Needed For Cruciate Rupture Genome-Wide Association Study
The Small Animal Orthopaedic Service is looking for two groups of dogs:
- PUREBRED Labrador Retrievers AND Rottweilers 8 years old or older with no history of cruciate rupture.
- PUREBRED Labrador Retrievers AND Rottweilers of any age that are affected with non-contact cranial cruciate rupture.
Having pedigree information is appreciated as study dogs should NOT be closely related to other study dogs. Enrolled dogs will receive a free clinical examination and radiographic assessment.
For more information and brochures, please visit http://www.vetmed.wisc.edu/lab/corl/canine-studies/ or email firstname.lastname@example.org
This study is looking at genetic predisposition to non-contact cranial cruciate rupture in Labrador Retrievers and Rottweilers using genomic sequencing. This study is supported by the Morris Animal Foundation, the Marjorie Siebert Aylen Foundation, the National Labrador Retriever Club and the AKC Canine Health Foundation.
Stem Cell Treatment for Dogs with Cruciate Rupture
The Small Animal Orthopaedic Service is able to offer stem cell treatment for medium to large breed dogs with unilateral non-contact cruciate rupture. Based on results of a recent clinical trial, we can offer treatment with autologous (self) stem cell treatment as a disease-modifying treatment for stable partial cruciate rupture. At the time of tibial plateau leveling osteotomy (TPLO) treatment of the knee with cruciate rupture, bone marrow will be aspirated from the adjacent thigh bone. Mesenchymal stem cells will be isolated and cultured. Treatment with stem cells will be given at a follow-up visit about 6 weeks after surgery. This treatment reduces knee joint inflammation and may promote healing of the cruciate ligaments of the second knee.
For dogs enrolled in the study, stem cell treatment will be given by the Small Animal Orthopaedic Service at UW Veterinary Care, University of Wisconsin-Madison. Owner treatment costs include the TPLO and preparation of the stem cell treatment.
For more information, please visit http://www.vetmed.wisc.edu/lab/corl/canine-studies/
If this trial demonstrates that treatment with bone marrow-derived autologous stem cells is an effective disease-modifying treatment for non-contact cruciate rupture, we anticipate that this treatment will be offered routinely through UW Veterinary Care. This program of work has been supported by the Veterinary Orthopaedic Society.
Horses needed for study of superficial digital flexor tendon problems and suspensory ligament problems
The Large Animal Surgery Service is looking for horses of all breeds with superficial digital flexor tendon problems or suspensory ligament problems. We are enrolling horses in two clinical trials:
- Clinical trial investigating a new ultrasound technique to aid in the rehabilitation of tendons in the horse.
- Clinical trial investigating genome-wide association with certain tendon injuries in the horse.
We will obtain the following:
- Blood sample (10 ml in EDTA tube)
- Ultrasound examination of the affected tendon/ligament as well as the contralateral limb
For more information please visit http://www.vetmed.wisc.edu/lab/corl/equine-studies/ to determine if you horse is eligible for any of these studies, please contact Dr. Sabrina Brounts at (608)-263-7600 or email@example.com